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From Dr. Joseph Mercola
Since COVID-19 first entered the scene, change of concepts has principally been outlawed. By sharing my views and people from numerous specialists all through the pandemic on COVID therapies and the experimental COVID jabs, I turned a most important goal of the White Home, the political institution and the worldwide cabal.
Propaganda and pervasive censorship have been deployed to grab management over each a part of your life, together with your well being, funds and meals provide. The most important media are key gamers and have been instrumental in creating and fueling concern.
I’m republishing this text in its authentic kind so that you could see how the development unfolded.
Initially printed: April 25, 2020
Molecular hydrogen (H2 gasoline) has highly effective antioxidant and anti inflammatory results,1 as defined on this video by Tyler W. LeBaron, founding father of the science-based nonprofit Molecular Hydrogen Institute.
In his video, LeBaron evaluations the pathophysiology of COVID-19 and explains why H2 is being clinically investigated by discussing the proposed mechanisms of how molecular hydrogen would possibly ameliorate illness.
Actually, a number of Chinese language investigators are utilizing H2 remedy in COVID-19 sufferers,2,3 and preliminary outcomes4,5 are encouraging sufficient that Dr. Zhong Nanshan, the epidemiologist who found the SARS virus (SARS-CoV-1) in 2003, is now recommending H2 remedy for COVID-19.6
Whereas extra analysis is required to verify advantages and useful outcomes in COVID-19 circumstances, the newest COVID-19 remedy information7 by the Chinese language Nationwide Well being Fee contains hydrogen inhalation.
LeBaron features a video clip of Chinese language sufferers given a hydrogen-oxygen inhaler combine, who say it eradicated chest ache and cough, and allowed for deeper respiratory with out discomfort. That stated, LeBaron notes:
“There may be nonetheless no clinically printed proof that H2 will actually profit COVID-19 and this info is solely for academic functions. It doesn’t represent medical proof, and isn’t supposed to exchange the steerage out of your well being care practitioner.”
Pathophysiology of COVID-19
As defined by LeBaron, the SARS-CoV-2 virus answerable for COVID-19 enters the lungs, the place it assaults the kind 2 pneumocytes,8 alveolar cells answerable for the secretion of surfactants that cut back the floor stress of fluids in your lungs and are thus essential for elasticity.
The SARS-CoV-2 virus makes use of a spiked protein to anchor itself to the ACE-2 receptor9 of the cell. That is the way it positive aspects entry and releases its positive-sense single-strand RNA into the cell. By inserting its RNA, the virus primarily hijacks the cell, because it triggers viral replication to happen contained in the cell.
In response, macrophages (white blood cells) are activated to fight the an infection, and so they in flip launch quite a lot of cytokines, together with interleukin-6 (Il-6), IL-1 and TNF-alpha, into your blood plasma. As soon as the cytokines enter your plasma, neutrophils are recruited, thus growing vasodilation (growth of your blood vessels) and capillary permeability.
Contained in the cell, reactive oxygen species (ROS) are additionally created in an effort to kill the contaminated cell and forestall viral replication. That is a necessary a part of your physique’s protection system. Nonetheless, as the method progresses you find yourself with growing quantities of ROS and irritation. Worse, because the virus continues to assault your sort 2 pneumocytes, your lungs can not work accurately.
Because the floor stress of the fluids in your lungs is decreased, your alveoli can not preserve the right gasoline change, and your oxygen requirement goes up. Declining elasticity of the lungs additionally makes respiratory tougher. Add in excessive quantities of ROS, and the entire alveoli finally ends up dying. That is a part of what’s inflicting the cough.
As irritation and vasodilation progresses, you possibly can find yourself with low blood strain, which is why you’re feeling fatigued and weak. Decrease blood strain additionally causes low blood perfusion, which in flip means your cells won’t get the oxygen and vitamins they want for optimum perform. It additionally impairs metabolic waste removing. The low oxygen ranges (hypoxia) lead to feeling in need of breath.
Until efficiently handled, this chain of occasions results in cell demise, multi-system organ failure (lungs, liver and kidneys), acute respiratory misery (ARD) and, in the end, demise.
Stopping the Harmful Cycle
To save lots of the affected person, one thing must be performed to cease this harmful cascade of occasions. How can we inhibit viral replication and increase immune system perform? As defined by LeBaron, many of the destruction happens by ROS and systemic irritation.
ROS are molecules that trigger oxidative injury. Nonetheless, they are not all unhealthy on a regular basis. Neutrophils that produce ROS additionally produce nitric oxide and superoxide, that are essential. Superoxide helps kill the pathogen, however you additionally don’t desire an excessive amount of of it, so it must be regulated.
Nitric oxide additionally must be regulated. Whereas it could inhibit viral replication and helps increase your immune system, you don’t need an excessive amount of. As ranges of superoxide and nitric oxide rise, they begin forming peroxynitrites, that are extraordinarily damaging, which in flip kind hydroxyl radicals, essentially the most cytotoxic ROS.
Usually, when superoxide has performed its job, it is transformed by superoxide dismutase into hydrogen peroxide, which in flip is transformed into water and oxygen.
This course of is regulated by a transcription issue referred to as Nrf2/keap1. When this transcription issue is activated, it goes into the cell’s nucleus, the place it binds with the antioxidant response aspect (ARE), which triggers your physique’s pure antioxidants comparable to glutathione and catalase.
As famous by LeBaron, Nrf2 — which is concerned in part 2 detoxing — regulates greater than 200 protecting proteins and enzymes. The issue is that when ROS is overabundant and uncontrolled, the Nrf2 system is depleted and may not regulate the inflammatory course of.
Understanding Molecular Hydrogen
Molecular hydrogen or H2 has the flexibility to activate the Nrf2/keap1 pathway, thereby replenishing your endogenous antioxidants. In so doing, H2 helps regulate and preserve homeostasis in the entire system, stopping the an infection from getting uncontrolled and inflicting cell demise.
Hydrogen can even downregulate NOX and NOS enzymes, thus reducing superoxide and nitric oxide manufacturing respectively. That is good, as when these two molecules are elevated an excessive amount of they immediately mix to create the pernicious peroxynitrite molecule. H2 additionally helps your mitochondrial perform. Importantly, H2 selectively reduces peroxynitrites and hydroxyl radicals.
This provides H2 a big benefit over different antioxidants comparable to vitamin C, which act indiscriminately with superoxide and nitric oxide — each of which even have essential and useful capabilities. H2 doesn’t work together with both superoxide or nitric oxide. The one factor H2 can react with are essentially the most harmful ROS comparable to peroxynitrites and hydroxyl radicals.10
Consequently, your superoxide and nitric oxide are left to carry out useful capabilities whereas the H2 eliminates essentially the most harmful byproducts of superoxide and nitric oxide, whereas concurrently growing your physique’s pure manufacturing of antioxidants and regulating the enzymes that produce superoxide and nitric oxide. To get a clearer image in your thoughts of how H2 steps in to interrupt the harmful chain, see LeBaron’s video.
H2 additionally steps in to forestall a cytokine storm from occurring. A cytokine storm happens when the upregulation of cytokines is larger than your physique can deal with. Cytokines are regulated by transcription elements, and ROS regulate these transcription elements. Inflammatory transcription elements, in flip, create extra irritation, which stimulate extra ROS manufacturing.
This can be a vicious cycle that leads to elevated cell demise, which results in multiorgan failure, which results in demise. H2 has been proven to manage these transcription elements in a number of animal and human research, thus breaking the vicious cycle. That is what makes H2 so anti-inflammatory. As summarized by LeBaron on the finish of his video:
“Hydrogen gasoline, being a quite simple, small molecule, can assist to manage the redox standing of the cell by selectively lowering the very unhealthy [ROS], assist to manage and enhance the Nrf2/keap1 pathway to keep up our physique’s redox homeostasis.
It additionally has regulatory results on irritation, to decrease persistent, dangerous systemic irritation by regulating the whole lot. Simply lowering or inhibiting it [referring to ROS] is just not need we need to do. We want all of this stuff.
That is in our immune system. We do not simply need to eliminate it. Sure, it’s what’s killing us, however additionally it is essential to have, in order that we will get higher. So, that’s the … rationale for [using hydrogen gas] for COVID-19.”
Dosing and Availability
Though the precise medical research on COVID-19 are being performed with H2 inhalation, H2 dissolved in water has been proven to be more practical than inhalation in different animal illness fashions.11 Moreover, one other article12 means that the H2-infused nitric oxide-producing beverage from H2Bev referred to as HydroShot, must also be clinically investigated for its reported preliminary results.
Nonetheless, whereas there are numerous methods of getting H2, the only and most sensible supply system is molecular hydrogen tablets which can be dissolved in water. They’re transportable and might be taken anyplace, together with journey and on airways, and so they constantly present a excessive H2 focus. When utilizing the tablets it is essential to drink the water as quickly because the tablets are dissolved and the water continues to be “white,” because the H2 dissipates rapidly.
The molecular hydrogen tablets have the extra benefit of offering 80 mg of ionic elemental magnesium with every pill. Magnesium can function a pure calcium channel blocker to assist regulate excessive intracellular calcium ranges that may wreak havoc in your physique.
Additionally, absolutely the amount of H2 is much much less essential than pulsing or creating an acute elevation of H2 in your system over a brief interval. That acute elevation is what prompts the Nrf2 pathway. When publicity is steady, even when elevated, it has nearly no impact.
Clearly, we’d like extra analysis to be higher capable of reply dosing questions, however within the interim, it appears customizing the dose to your private circumstances can be most acceptable. So, in case you’re in regular, non-stressful circumstances at dwelling, probably not doing something very demanding and never exercising a lot, perhaps taking H2 as soon as a day is ample.
Nonetheless, in case you train lots, chances are you’ll need to take it two to 3 occasions a day to assist cut back the oxidative stress out of your train. Ditto in case you’re touring and exposing your self to free radical stress from ionizing radiation at 35,000 ft. In such a circumstance, it is perhaps acceptable to take it each two hours whilst you’re within the air.
Contemplating their security, ease of use, and useful results on immune perform and well being, molecular hydrogen tablets are a no brainer resolution in my opinion, and so they may very well be fairly useful for a lot of situations, together with COVID-19, which is why H2 is being clinically investigated.
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