Police and emergency crews had been known as to a North Highway tackle within the suburb of Ormond about 1am to seek out two males injured.
One man, who’s but to be formally recognized, died on the scene.
The opposite man, aged 30, was taken to hospital with non-life-threatening accidents.
North Highway is cordoned off to west-bound visitors between Bethell Avenue and OLoughlan Steet.
A criminal offense scene has been established and police are investigating.